Research has shown polyphenol compounds may reduce the growth and pain of lesions found in recurrent canker sores by providing anti-inflammatory, antioxidant, and caustic properties.

One size doesn’t fit all and every patient is unique. Drug compounding is the process of combining, mixing, or altering ingredients to create a medication tailored to the needs of a patient by a pharmacist as the result of a practitioner’s prescription drug order. While compounded medications are not FDA-approved, they serve an important patient need—especially when FDA-approved medication is not available for treatment. Our formulations are made to order in small batches to ensure freshness. The specific ingredients in your compounded formula will depend on your specific concerns and goals. It should be understood that your personal healthcare practitioner will make the final decision.

Yes! All of our compounded formulations, regardless of ingredients, are eligible for Flexible Spending Accounts (FSA) and Health Saving Accounts (HSA).

Recurrent aphthous stomatitis (RAS) or canker sores occur in 20-60% of all persons. Canker sores, also called aphthous ulcers, are small, shallow lesions that develop inside your mouth, under the tongue, inside your cheeks, or at the base of your gums. Unlike cold sores, canker sores aren't contagious; however, they can be just as painful. Most canker sores are round or oval with a white or yellow center and a red border. Canker sores may be recurring and can last for two weeks or more.

Based on research and patient testimonials, you may see improvement as early as 30 to 60 seconds after application; however, each patient is unique and time frames may differ.

• The Canker Sore Formula is for oral cavity use only. Do not use it on any other part of your body. If this medicine gets in your eyes, rinse with water.

• Follow all directions on your prescription label. Using this medicine in larger amounts or applying it more often than prescribed will not make it work any faster, and it may increase side effects such as irritation.

• Wash your hands with soap and water before and after applying the medicine. Do not allow other people to get this medicine on their skin. If this happens, wash the area thoroughly with soap and water.

• Immediately before applying solution thoroughly dry the ulcerated area of oral mucosa that is to be treated.

• Open the cap of your drop bottle and gently saturate the tip of your cotton swap (i.e. Q-tip®) with the medicated solution (reddish-brown viscous liquid).

• After drying the lesion, hold the saturated cotton applicator swab to the dried ulcer area for at least 15 seconds.

Do not start using the Canker Sore Formula if you have a history of hypersensitivity to the prescribed ingredients. The prescribed ingredients may include, but are not limited to; polyphenol sulfonic acid. Talk to your doctor or pharmacist if you are pregnant or breast-feeding a baby.

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

Store at room temperature away from moisture and heat between 68°F to 77°F (20°C to 25°C).

Research has shown, topically applied medications are less likely to cause the same systemic side effects or drug-to-drug interactions as oral medications; however, there is never an absolute zero chance that side effects or drug interactions will not occur. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

What are the common side effects of the Canker Sore Formula?

Although the risk of serious side effects is low when the Canker Sore Formula is applied to the aphthous ulcer, this medicine can be absorbed through the skin.

• Keep out of reach of children.

• Because of its nature, prolonged use of the Canker Sore Formula on normal tissue should be avoided.

• The Canker Sore Formula is for use in the oral cavity only. Avoid eye contact. If eye exposure occurs, immediately remove any contact lenses and irrigate eyes for at least 15 minutes with lukewarm water.

Get emergency medical help if you have signs of an allergic reaction: hives, severe itching; difficult breathing; swelling of your face, lips, tongue, or throat. These are not all of the possible side effects of the Canker Sore Formula. For more information, ask your healthcare provider or pharmacist. Tell your healthcare provider if you have any side effects that bother you or do not go away.

What happens if I overdose?

An overdose is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed excess amounts of the medication.

• Fields S. Treating mouth ulcers. Pharmacy Times. 2005;11:96.

• Farzaei MH, Abdollahi M, Rahimi R. Role of dietary polyphenols in the management of peptic ulcer. World J Gastroenterol. 2015 Jun 7;21(21):6499-517. doi: 10.3748/wjg.v21.i21.6499. PMID: 26074689; PMCID: PMC4458761.

All prescription medications require a valid and complete online consultation prior to approval and final pricing is determined. All compounded medications in the U.S. are considered off-label use. Licensed healthcare practitioners have the ability to prescribe compounds for off-label treatment, if they believe that it is an appropriate course of treatment.

The drug and medical information provided on this website is not meant to cover all adverse effects, drug interactions, warnings, medical uses, directions and precautions. The information provided is a medical resource and the judgment of your physician and/or healthcare practitioner should not be substituted. Premier Pharmacy has made every effort to ensure the information on the website is accurate and current based on present medical literature.

Premier Pharmacy does not make any guarantees regarding the drug and medical information, and does not assume responsibility regarding the content. The drug safety and drug information contained on the website may be time sensitive and should not be utilized as a medical reference beyond the date hereof. The deficiency of a warning for prescription medications and vitamins provided on this website in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient.

If you have questions or concerns about your medications, please do not hesitate to contact us and/or your medical practitioner, including your pharmacist. Compound prescription products have not been tested or approved by the FDA for their intended use. No claims are made as to the safety, efficacy or use of this compound.