Diabetic Ulcer Formulas

Wound healing should come naturally, but sometimes due to complications, poor circulation or infection, the healing process can be slow or difficult which can result in wounds that are hard to heal. Various active pharmaceutical ingredients are prescribed by physicians for the treatment of wounds in compounded medications.

What is the Diabetic Ulcer Formula?

The Diabetic Ulcer Formula combines prescription ingredients in a proprietary base developed specifically to deliver ingredients to the affected area(s). It uses a unique delivery system designed to feel light, smooth and creamy with a pleasant finish on the skin. It is also not tacky or oily, leaving a light and silky feel on the skin. The Diabetic Ulcer Formula is specifically made without fragrance or gluten.

Common Ingredients

Beta Glucan

Beta-glucans are soluble fibers that come from the cell walls of mushrooms, plants, algae, yeasts, and oats. Because beta-glucans have antioxidant properties and are anti-inflammatory, they are excellent ingredients for improving the look of redness and other signs of sensitive skin.


Clindamycin is used to treat certain types of bacterial infections, including infections of the lungs, skin, blood, female reproductive organs, and internal organs. Clindamycin is in a class of medications called lincomycin antibiotics. It works by slowing or stopping the growth of bacteria.


Doxycycline is used to treat certain types of bacterial infections, including infections of the lungs, skin, blood, female reproductive organs, and internal organs. Doxycycline is in a class of medications called tetracycline antibiotics. It works by slowing or stopping the growth of bacteria.


Gentamicin is used to treat or prevent infections on the skin due to certain strains of Pseudomonas aeruginosa bacteria. This medicine works by killing bacteria or preventing their growth.


Levofloxacin belongs to a class of medications called Fluoroquinolone antibiotics. It is considered a broad-spectrum antibiotic that covers pathogens that are involved in skin infections, and an added advantage is that it is effective in attacking organisms that are becoming resistant.


Metronidazole has been reported to result in a reduction or eradication of wound odor, decrease in wound drainage, improvement in wound appearance, decrease in surrounding cellulitis, halting of tissue necrosis, and decrease in pain.


Misoprostol is a synthetic analogue of prostaglandin E1 that is known to reduce the inflammatory process and promote collagen formation in wounds. Research has shown topical misoprostol may decrease the healing time of acute wounds.


Mupirocin is used to treat or prevent infections on the skin due to certain strains of resistant Staphylococcus aureus bacteria. This medicine works by killing bacteria or preventing their growth.


Nifedipine belongs to a class of medications called calcium channel blockers (CCB). CCBs are known to have vasodilatory properties, increasing blood flow to the wound area and stimulating growth factor production.


Phenytoin may promote wound healing by a number of mechanisms, including stimulation of fibroblast proliferation, facilitation of collagen deposition, glucocorticoid antagonism, and antibacterial activity.


Vancomycin is used to treat or prevent infections on the skin due to certain strains of resistant Staphylococcus aureus bacteria. This medicine works by killing bacteria or preventing their growth.

Frequently asked questions

What is a compounded medication?

One size doesn’t fit all and every patient is unique. Drug compounding is the process of combining, mixing, or altering ingredients to create a medication tailored to the needs of a patient by a pharmacist as the result of a practitioner’s prescription drug order. While compounded medications are not FDA-approved, they serve an important patient need—especially when FDA-approved medication is not available for treatment. Our formulations are made to order in small batches to ensure freshness. The specific ingredients in your compounded formula will depend on your specific concerns and goals. It should be understood that your personal healthcare practitioner will make the final decision.

Are compounded medications FSA & HSA eligible?

Yes! All of our compounded formulations, regardless of ingredients, are eligible for Flexible Spending Accounts (FSA) and Health Saving Accounts (HSA).

What is a diabetic ulcer?

Diabetic ulcers are the most common foot injuries leading to lower extremity amputation. Open sores occur in approximately 15% of patients with diabetes. The most common risk factors for ulcer formation include diabetic neuropathy foot deformity and arterial blockage in the extremities.

Ulcers form due to a combination of factors, such as lack of feeling in the foot, poor circulation, foot deformities, irritation (such as friction or pressure), trauma, as well as the duration of diabetes. Patients who have had diabetes for many years can develop neuropathy, a reduced or complete lack of ability to feel pain in the feet due to nerve damage caused by elevated blood glucose levels over time. The nerve damage often can occur without pain and one may not even be aware of the problem.

When should I see improvement in my symptoms?

Based on research and patient testimonials, you may see improvement as early as 3 to 6 weeks; however, each patient is unique and time frames may differ.

How should I use the Diabetic Ulcer Formula?

  • The Diabetic Ulcer Formula is for topical use only. If this medicine gets in your eyes or mouth, rinse with water.

  • Follow all directions on your prescription label. Using this medicine in larger amounts or applying it more often than prescribed will not make it work any faster, and it may increase side effects such as irritation, and inflammation of skin.

  • Wash your hands with soap and water before and after applying the medicine. Do not allow other people to get this medicine on their skin. If this happens, wash the area thoroughly with soap and water.

  • Apply a thin layer to cover the affected area(s) one to two times daily or as directed.

  • The area treated may be covered with a gauze dressing if desired.

  • Care should be exercised to avoid further contamination of the infected skin.

Who should not use the Diabetic Ulcer Formula?

Do not start using the Diabetic Ulcer Formula if you have a history of hypersensitivity to the prescribed ingredients. Do not use this medicine if you are pregnant or breast-feeding a baby. Talk to your doctor or pharmacist before using if you have ever had: heart problems, liver disease or are currently taking delavirdine (Rescriptor) or birth control pills.

What happens if I miss a dose?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

How should I store this medication?

Store at room temperature away from moisture and heat between 68°F to 77°F (20°C to 25°C).

Safety Information

Research has shown, topically applied medications are less likely to cause the same systemic side effects or drug-to-drug interactions as oral medications; however, there is never an absolute zero chance that side effects or drug interactions will not occur. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

What should I avoid while using the Diabetic Ulcer Formula?

  • This drug product is contraindicated in individuals with a history of sensitivity to any of its components.

  • Do not use this medicine if you are pregnant or breast-feeding a baby.

What are the common side effects of the Diabetic Ulcer Formula?

Common side effects may include application site reactions of:

  • Skin reactions (dermatitis)

  • Burning, stinging or warmth

  • Itching or tingling

  • Redness, dryness or peeling

Get emergency medical help if you have signs of an allergic reaction: hives, severe itching; difficult breathing; swelling of your face, lips, tongue, or throat. These are not all of the possible side effects of the Diabetic Ulcer Formula. For more information, ask your healthcare provider or pharmacist. Tell your healthcare provider if you have any side effects that bother you or do not go away.

What happens if I overdose?

An overdose is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.


  • Saif AB, Jabbar S, Akhtar MS, Mushtaq A, Tariq M. Effects of topical Vancomycin Dressing on Methicillin-Resistant Staphylococcus Aureus (MRSA) positive diabetic foot ulcers. Pak J Med Sci. 2019 Jul-Aug;35(4):1099-1103. doi: 10.12669/pjms.35.4.368. PMID: 31372150; PMCID: PMC6659082.

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  • Tsai CC, Yang PS, Liu CL, Wu CJ, Hsu YC, Cheng SP. Comparison of topical mupirocin and gentamicin in the prevention of peritoneal dialysis-related infections: A systematic review and meta-analysis. Am J Surg. 2018 Jan;215(1):179-185. doi: 10.1016/j.amjsurg.2017.03.005. Epub 2017 Mar 15. PMID: 28341139.

  • Aykut S, Caner C, Ozkan G, Ali C, Tugba A, Zeynep G, Taner C. Mupirocin application at the exit site in peritoneal dialysis patients: five years of experience. Ren Fail. 2010 Jan;32(3):356-61. doi: 10.3109/08860221003611703. PMID: 20370452.


All prescription medications require a valid and complete online consultation prior to approval and final pricing is determined. All compounded medications in the U.S. are considered off-label use. Licensed healthcare practitioners have the ability to prescribe compounds for off-label treatment, if they believe that it is an appropriate course of treatment.

The drug and medical information provided on this website is not meant to cover all adverse effects, drug interactions, warnings, medical uses, directions and precautions. The information provided is a medical resource and the judgment of your physician and/or healthcare practitioner should not be substituted. Premier Pharmacy has made every effort to ensure the information on the website is accurate and current based on present medical literature.

Premier Pharmacy does not make any guarantees regarding the drug and medical information, and does not assume responsibility regarding the content. The drug safety and drug information contained on the website may be time sensitive and should not be utilized as a medical reference beyond the date hereof. The deficiency of a warning for prescription medications and vitamins provided on this website in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient.

If you have questions or concerns about your medications, please do not hesitate to contact us and/or your medical practitioner, including your pharmacist. Compound prescription products have not been tested or approved by the FDA for their intended use. No claims are made as to the safety, efficacy or use of this compound.