Wrinkle Formulas

The Wrinkle Formula is a customized prescription blend that may include ingredients such as; retinol, estrogen, vitamin B, C, and E, hydrating agents, and/or ceramide lipids that target the main symptoms of aging skin. This formulation may help reduce the appearance of wrinkles and fine lines most commonly found on the face and neck. It is an odorless gel typically applied once daily before bedtime.

What is the Wrinkle Formula?

The Wrinkle Formula combines prescription ingredients in a proprietary base developed specifically to deliver ingredients while moisturizing and softening the skin. It uses a unique delivery system designed to feel light, smooth and creamy with a pleasant finish on the skin. It is also not tacky or oily, leaving a light and silky feel on the skin. The Wrinkle Formula is specifically made without fragrance or gluten.

Common Ingredients

Beta Glucan

Beta-glucans are soluble fibers that come from the cell walls of mushrooms, plants, algae, yeasts, and oats. Because beta-glucans have antioxidant properties and are anti-inflammatory, they are excellent ingredients for improving the look of redness and other signs of sensitive skin.

Ceramides

Ceramides are essential lipids naturally produced in the body and make up nearly 50% of the outermost layer of skin. Ceramides help in creating a lipid barrier that helps boost skin resilience and prevents the skin from losing moisture. When the skin lacks ceramides, it can lead to dryness and irritation, contributing to skin sensitivity.

Estrogen

Estrogens are female hormones naturally produced by the body and are necessary for the normal sexual development of the female and for the regulation of the menstrual cycle during the childbearing years. The ovaries begin to produce less estrogen after menopause (the change of life). Estrogen replacement medicine is often prescribed to make up for the lower amount of estrogen. Topical estriol compounds have been shown to improve skin elasticity, firmness, and skin moisture all while decreasing wrinkle depth and pore size.

Hyaluronic Acid

Hyaluronic acid is naturally produced by the body and is found in high concentrations within the skin. Hyaluronic acid is essential for maintaining your skin's moisture balance and is responsible for your skin’s plumpness and volume. Hyaluronic acid has been shown to attract and retain water, making it an excellent hydrating ingredient. As we age, hyaluronic acid levels decline, which is why it’s important to supplement products that contain this ingredient.

Niacinamide

Niacinamide, also known as vitamin B3, plays an important role in soothing and helping to restore the skin barrier. Niacinamide has become a popular ingredient in formulations for acne, eczema, rosacea, and skin discoloration. When applied topically, niacinamide may help strengthen the skin's moisture barrier, which may help reduce the visible effects of skin damage.

Tretinoin

Tretinoin, a derivative of vitamin A, has been shown to help promote your skin’s natural exfoliation process. This exfoliation process encourages the shedding of dead skin cells, which may lead to improvement in the appearance of fine lines, wrinkles, texture, and uneven tone.

Vitamin C

Vitamin C is not produced naturally by the body; however, research has shown it offers multiple benefits for the skin. Vitamin C has been shown to be a potent antioxidant that helps against free radicals, which can lead to dryness, rough surface texture, and signs of premature aging. Research has also shown that Vitamin C may help brighten the appearance of uneven skin tone.

Vitamin E

Vitamin E research has shown it offers multiple benefits for your skin. Vitamin E has been shown to be a potent antioxidant that helps against free radicals, which can lead to dryness, rough surface texture, and signs of premature aging.

Frequently asked questions

What is a compounded medication?

One size doesn’t fit all and every patient is unique. Drug compounding is the process of combining, mixing, or altering ingredients to create a medication tailored to the needs of a patient by a pharmacist as the result of a practitioner’s prescription drug order. While compounded medications are not FDA-approved, they serve an important patient need—especially when FDA-approved medication is not available for treatment. Our formulations are made to order in small batches to ensure freshness. The specific ingredients in your compounded formula will depend on your specific concerns and goals. It should be understood that your personal healthcare practitioner will make the final decision.

Are compounded medications FSA & HSA eligible?

Yes! All of our compounded formulations, regardless of ingredients, are eligible for Flexible Spending Accounts (FSA) and Health Saving Accounts (HSA).

What are wrinkles?

Wrinkles may begin at a young age, but become more pronounced in those over 40 years of age. They usually begin as fine lines, progressing to deep creases, folds and crepey skin. Wrinkles are oftentimes more noticeable in skin on exposed areas of the body (i.e. face, neck, hands). Wrinkles can be caused by a combination of factors such as age, exposure to ultraviolet light, and smoking. By your 40’s, wrinkles mostly appear with animation of the face; by your 50’s, the creases become more permanent; and, by your 60’s, your whole face may be covered with wrinkles. Wrinkles resulting from aging are often deep and accompanied by skin laxity. Those wrinkles due to sun exposure are often advanced with texture changes.

When should I see improvement in my symptoms?

Based on research and patient testimonials, you may see improvement as early as 6 to 8 weeks; however, each patient is unique and time frames may differ.

How should I use the Wrinkle Formula?

  • The Wrinkle Formula is for topical use only. If this medicine gets in your eyes or mouth, rinse with water. Do not apply this medication to your eyelids.

  • Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

  • Wash your hands with soap and water before and after applying the medicine. Do not allow other people to get this medicine on their skin. If this happens, wash the area thoroughly with soap and water.

  • Wash and gently dry your skin before and after applying. Clean the affected area with a mild soap or a soap-free cleansing lotion and pat dry with a soft towel.

  • Apply a thin layer to the affected area(s) once daily before bedtime.

  • If your skin becomes too dry or sensitive, you may want to apply every other day instead

  • Do not apply to sunburned, windburned, dry, chapped, irritated, or broken skin.

  • Do not apply when skin is HOT (directly after showering or workout)

  • Do not cover treated skin with a bandage. Bandaging can increase the amount of drug absorbed through your skin and may cause harmful effects.

  • Do not allow a child to come into contact with the skin where you have applied estrogens topically. Topical estrogen is absorbed through the skin and can cause premature puberty in a child who comes into contact with this medicine. Cover treated areas with clothing to protect others from coming into contact with the skin where you apply this medicine.

  • The Wrinkle Formula should be used as part of a complete skin care program that includes avoiding sunlight, using an effective mineral based broad-spectrum sunscreen daily, and wearing protective clothing.

  • If incorporating additional products, it is recommended to follow the following order: cleanser, Wrinkle Formula, serum, moisturizer, sunscreen and makeup.

  • Wait for at least 20 minutes before applying moisturizer or any other skincare products.

Who should not use the Hot Flash Formula?

Do not start using the Wrinkle Formula if you:

  • Have unusual vaginal bleeding

    • Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

  • Currently have or have had certain cancers

    • Estrogens may increase the chance of getting certain types of cancer, including cancer of the breast or uterus. If you have or have had cancer, talk with your healthcare provider about whether you should use the Hot Flash Formula.

  • Had a stroke or heart attack

  • Currently have or have had blood clots

  • Have been diagnosed with a bleeding disorder

  • Have a history of hypersensitivity to any of the ingredients prescribed

  • Think you may be pregnant

    • The Wrinkle Formula is not for pregnant women. If you think you may be pregnant, you should have a pregnancy test and know the results. Do not use the Wrinkle Formula if the test is positive and talk to your healthcare provider.

What happens if I miss a dose?

Use the missed dose as soon as you remember, or wait until the next night to apply the medicine. Do not use extra medicine to make up for the missed dose.

How should I store this medication?

Store at room temperature away from moisture and heat between 68°F to 77°F (20°C to 25°C).

Safety Information

Research has shown, topically applied medications are less likely to cause the same systemic side effects or drug-to-drug interactions as oral medications; however, there is never an absolute zero chance that side effects or drug interactions will not occur. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

What should I avoid while using the Wrinkle Formula?

  • Avoid exposure to sunlight or tanning beds. The Wrinkle Formula can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

  • Wait at least 25 minutes after applying topical estrogen before you apply sunscreen to the same skin area.

  • Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using estrogens and progesterone.

  • Grapefruit may interact with estrogen and lead to unwanted side effects. Avoid the use of grapefruit products.

  • Avoid using other products that may contain duplicate ingredients prescribed.

  • Your skin may be more sensitive to weather extremes such as cold and wind. Protect your skin with clothing and use a moisturizing cream or lotion as needed.

  • Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.


What are the common side effects of the Wrinkle Formula?

Common side effects may include application site reactions of:

  • Skin reactions (dermatitis)

  • Burning, stinging or warmth

  • Itching or tingling

  • Redness, dryness or peeling

  • Change in skin color


Less serious, but common side effects of estrogen use includes:

  • Headache

  • Breast pain

  • Stomach or abdominal cramps, bloating

  • Nausea and vomiting

  • Hair loss

  • Fluid retention

  • Vaginal yeast infection


Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

  • New breast lumps

  • Unusual vaginal bleeding

  • Changes in vision or speech

  • Sudden new severe headaches

  • Severe pains in your chest or legs with or without shortness of breath, weakness and fatigue


Serious, but less common side effects of estrogen use includes:

  • Heart attack

  • Stroke

  • Blood clots

  • Dementia

  • Breast cancer

  • Cancer of the lining of the uterus (womb)

  • Cancer of the ovary

  • High blood pressure

  • High blood glucose

  • Gallbladder disease

  • Liver problems

  • Changes in your thyroid hormone levels

  • Enlargement of benign tumors (“fibroids”)


Get emergency medical help if you have signs of an allergic reaction: hives, severe itching; difficult breathing; swelling of your face, lips, tongue, or throat. These are not all of the possible side effects of the Wrinkle Formula. For more information, ask your healthcare provider or pharmacist. Tell your healthcare provider if you have any side effects that bother you or do not go away.


What happens if I overdose?

Overdose is unlikely; however, symptoms may include nausea, vomiting, stomach pain, breast tenderness, drowsiness, and vaginal bleeding. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

References

  • Khavkin J, Ellis DA. Aging skin: histology, physiology, and pathology. Facial Plast Surg Clin North Am. 2011 May;19(2):229-34. doi: 10.1016/j.fsc.2011.04.003. PMID: 21763983.

  • Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A. Treatment of skin aging with topical estrogens. Int J Dermatol. 1996 Sep;35(9):669-74. doi: 10.1111/j.1365-4362.1996.tb03701.x. PMID: 8876303.

  • Schmidt JB, Binder M, Macheiner W, Kainz C, Gitsch G, Bieglmayer C. Treatment of skin ageing symptoms in perimenopausal females with estrogen compounds. A pilot study. Maturitas. 1994 Nov;20(1):25-30. doi: 10.1016/0378-5122(94)90097-3. PMID: 7877517.

  • Bissett DL, Oblong JE, Berge CA. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005 Jul;31(7 Pt 2):860-5; discussion 865. doi: 10.1111/j.1524-4725.2005.31732. PMID: 16029679.

  • Fu JJ, Hillebrand GG, Raleigh P, Li J, Marmor MJ, Bertucci V, Grimes PE, Mandy SH, Perez MI, Weinkle SH, Kaczvinsky JR. A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen. Br J Dermatol. 2010 Mar;162(3):647-54. doi: 10.1111/j.1365-2133.2009.09436.x. PMID: 20374604; PMCID: PMC2841824.

  • Humbert PG, Haftek M, Creidi P, Lapière C, Nusgens B, Richard A, Schmitt D, Rougier A, Zahouani H. Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo. Exp Dermatol. 2003 Jun;12(3):237-44. doi: 10.1034/j.1600-0625.2003.00008.x. PMID: 12823436.

Disclaimer

All prescription medications require a valid and complete online consultation prior to approval and final pricing is determined. All compounded medications in the U.S. are considered off-label use. Licensed healthcare practitioners have the ability to prescribe compounds for off-label treatment, if they believe that it is an appropriate course of treatment.


The drug and medical information provided on this website is not meant to cover all adverse effects, drug interactions, warnings, medical uses, directions and precautions. The information provided is a medical resource and the judgment of your physician and/or healthcare practitioner should not be substituted. Premier Pharmacy has made every effort to ensure the information on the website is accurate and current based on present medical literature.


Premier Pharmacy does not make any guarantees regarding the drug and medical information, and does not assume responsibility regarding the content. The drug safety and drug information contained on the website may be time sensitive and should not be utilized as a medical reference beyond the date hereof. The deficiency of a warning for prescription medications and vitamins provided on this website in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient.


If you have questions or concerns about your medications, please do not hesitate to contact us and/or your medical practitioner, including your pharmacist. Compound prescription products have not been tested or approved by the FDA for their intended use. No claims are made as to the safety, efficacy or use of this compound.